440 with 452 heads and high compression?

Hey guys, I've heard a thing or two about how you shouldn't go high compression with open chamber heads, yet i also see guys having done just that. It just so happens that my 440 has 452 heads with 2.14"/1.81" valves, pocket porting and blended bowls, along with gasket matched intake runners and a gasket matched tunnel ram. That woke her up immensely, but I'm still running on factory turd pistons with 1.91 compression height and 90cc combustion chambers, coming out to like 7.8:1 compression. I found a set of ICON forged pistons, 2.067" compression height and 5.6cc domes, which should bring it to 0.015" deck clearance for 10.27:1 compression, according to the calculator I'm using. Is this high of compression too high for open chambers, and if so, why? If I had the heads and intake milled to raise the compression further, couldn't i just run race gas, like 100 octane? Or would the lack of quench cause further issues with combustion?