Interesting that it shot lean so quickly. I've gone done the track with the pressure dropping from 3-4 psi to zero but there was enough fuel to make to the line. We thought it was the pump but it turned out to be the feed line.
Vapor lock would/will occur if a portion of the line gets heat soaked. Hard to see how that would happen during the run and not other times but its possible. Has only happened to me when there's still winter fuel in the tank, and the weather is hot. Make sure your lines are away from heat and or insulated. If there's any pre-June fuel in the tank - get rid of it.
This all assuming the AFR gage is telling you fuel in the bowl ran very low.