Then I would just cool thechitoutofit,until it she quits detonating, then reintroducing the heat little by little to get the power back.
And that starts with;
Colder plugs, a slower timing curve, perhaps slightly limited total timing,then clean out the chambers with a chemical treatment, and then attack the cooling system. And finally check the exhaust system.
I know you said you did the math and got 9.9 Static compression ratio. With that cam in at 106, the Ica comes to 69*. But with the Hughes people measuring their cams at .008tappet lift, the Ica is actually much later. So IMO,You should have no problem tuning this puppy at 9.9 calculated Scr.
You should be getting about 10/11" of manifold vacuum with a proper Transfer-slot sync,at 750/800rpm, with that cam properly installed and no vacuum leaks. With the transfer slot properly set, your timing might come in around 14 to 16 degrees. Forget about all other timings for now. Just work on the getting the transfer slot right and the idle to 750/800 FIRST, then get the vacuum stable and see if it comes in close to 10/11.