I now set my cruise A/F ratio with the main jets. You'll be surprised how small the MJ can be if the PV opens at the correct time, and you tune for WOT with the power valve restricter channel.
I'm seeing that. While this carb I have is race oriented, as well as test run on an unknown spec engine, I'm working on as best a happy medium strip/street deal. Was jetted with 76/87 jets with 4.5 PV, etc. Baby steps at the moment, at 75 on primaries, just did a good test run and cruise up to 3000 I've got a good 17"-18" afr hovering about 13, and think 72-73's will put me at about 14 or so. But with bigger cruise/steady load on primaries (no pump in play) it climbs up to 15+ and vacuum is near to 10-12" region. So I know the PV is still in REM mode at that point and it'll take tweaking on, if I'm reading the good book and other resources correctly