Holley/Demon Carb stumble
Too large regardless whether its top, bottom or middle.
Some say submerged location can be a little smaller if everything else is the same.
The logic is submerged restricts the flow of solid fuel (liquid). Mark W has mentioned its real. I've just moved them and can't show you a direct comparison without any other variables.
IMO 0.035" dia is about as large as it ought to be. Maybe .037 in some cases, especially if high, but I wouldn't start that large. IIRC .031 or .033 was primary on the 3310-1, 2, 3s and IFRs were around .076
Wish I had an unmolested 4780 or something close to what you have there to look at, but I don't.
I think there was an older Holley 4150 dp that had downlegs on all 4 but don't remember the number, nor did I ever actually own one. Would have to ask one of the guys with notes on lots of different carbs.