The bigger the lifter, the more lift per degree of rotation you can have. And it is a case where most of the time, you are better off with a faster lobe.
Why? Because you can cut the seat duration way down, still get the at .050 timing you need for your application.
If you are building milquetoast stuff then it mostly may not matter. Even then, I can't see why you'd not take advantage of the bigger lifter.