Depends on the engine and what you want out of it. A single 4bbl on a dual plane air gap makes plenty of HP and is easy to tune. It’s only when racing that the minor advantages of the others come into play for a specific build.
First ask yourself what you will be using the car for and how you will be able to drive it 90% of the time...and then go from there.
Too many people have overbuilt street motors only to be disappointed with driveability for what they want to use it for most...and they sit parked in their garage because they just aren’t fun to drive or take on a casual cruise on a whim.