Do NOT drill out the squirter cluster until you know you need a bigger shot.
The vent should remain open and not plugged up since it releases built up pressure that occurs from time to time within the fuel bowls. Fuel will not spill out. Reinstall it with a dab of lock tight for piles and tap it in if need be until it seats.
The secondary side should have absolutely ZERO issues contacting the intake manifold when the spaced is used.
Zero, none, Na-da, Zilch, etc