Intermittent spark

Have any of you heard of spark plugs getting so fouled they don’t spark at all?
After replacing my distributor pickup with the one from the old distributor, the coil wire will spark on the intake manifold perfectly fine now when it’s disconnected but the engine still won’t fire when I hook everything back up. I’ve pulled the #1 plug to find TDC to make sure the timing is at least close but still no fire. My plugs are extremely fouled because I never got the chance to tune the carb. That’s what I was about to do when all of this happened.
image.jpg. Edit: I’ve removed the spark plug from the head and set it on the intake manifold plugged into the distributor and spun the distributor shaft by hand. It sparks just like any other plug I’ve seen. I don’t understand why this thing won’t fire up.