High compression and turbo

What YR said. Leave regular fuel system as is and then alcohol for nitrous enrichment in the second fuel system (didn't fully clarify that). Or use e98 for a big dose of nitrous. e98 has a very high latent heat of evaporation rating and will cool as much as methanol for a given amount of nitrous even though the fuel enrichment is close to half for ethanol vs. methanol. I was going to mention E85, but only in drums unless you plan on a fuel density meter with input into engine management for fuel control. Pump e85 is still a crap shoot, at best. It runs from 51% to 90% blend just depending on what the vendor is trying to predict is going to yield the highest profit and least amount of potential trouble for FlexFuel vehicles using it. If I chose to go with pump e85, I'd keep e98 on hand and use a hydrometer to blend fuel to the tune, being I prefer the simplicity of the analog world. But either way you go, the chambers are going to need opened up. Overall, I think boost with some compression drop from softening the chambers and some thicker gaskets to minimize quench (along with adding water/methanol injection) would be doable, but not practical. The more compression you can get out of it, the better. I can say from experience that 8 PSI of Roots boost on top of 9.5:1 compression is fairly unmanageable for most street usage.