High compression and turbo

HOTMOPR said

12-1 compression at 8 psi is roughly a 18.5 -1 effective compression ratio. Choose your fuel and tune wisely.. I would talk to a legit turbo cam grinder for your build.

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I'm thinking if I go turbo, I'll have to change a couple things which will bring the compression to about 11.5:1. I might just build everything to run on methanol, this isn't really a daily driver. More of a car meet and track car now. And of course I wont' use the cam I have, I'll have one spec'd out for a turbo.

Another question. If I go forward with this insanity, Which turbo? I was thinking somewhere around S480 sized. Or would there be a benefit to running two smaller turbos?