1957 DeSoto 8 3/4"

You would have to change the axle ends to make the Flange axles work. I would find a latter model, maybe a 68-70 B body 8 3/4" rear housing? I don't know what your rear housing measures.

Roy is correct. The axle housing ends need to be cut off and the correct ones welded on. This is a very simple, straight forward procedure, even if not done yourself. Very affordable to pay someone to do, so don't let it deter you from doing this.