Yes! I also love the Thrush Turbo, flows well and quiet at idle and cruise with full exhaust but sounds great when the throttle is down. No droning from what i can tell. Others might have a different experience. Plus they are relatively cheap! Summit branded turbo mufflers are the same as thrush i believe. Ive used both and dont hear a difference.
I havent been on here in so long! To answer the original question with my personal experience. I put a 5.2 in my 73 dodge D100 with an Edelbrock RPM and 600 Edelbrock carb on top. With no tuning I am getting 15ish mpg on the interstate at 65. The same MPG i got when the engine was in the Dakota i pulled it from. So no cam change is necessary for it to run. However is it optimal from a scientific standpoint comparing fuel injection to carb? I have no clue. I i didnt read the whole thread. So yes it will work but may not be optimal?