pretty much runs along the Mississippi river up to the Ohio River Valley. Not near as active as the San Andreas, but when it goes, it has a much higher likelihood of being a high 6 or high earthquake. And its all in bedrock so the earthquake travels out 5-10 times farther than an earthquake in say CA or the west coast. About 150 years ago, they had an earthquake so powerful, the mississippi river reversed course and flowed south to north.