EFI options
I would recommend running a port injection systems over a TB set up - Tuning and sensor inputs would be a little more work but it would allow for more tuning capabilities compared to a self learning TB system.
I am working with an MS3X for my 6.1 and it is proving to be quite fun to wire up and get started. I wanted to learn more about EFI systems and tuning so I decided to go with the MS3X as it requires way more work to set up. However, it is just as capable as most high line EFI systems and just as versatile.
The Holley system would allow for a rather quick install and offers huge amounts of technical support through their forums. The Holley systems are also reasonably priced these days to boot.