Cams choice, Low CR vs VE%

increasing the horsepower, can only be done by increasing the amount of fuel burned, which can only be done by ingesting more air, which points straight to a higher VE; they are inextricably related.
How you get the additional air, well that can be complicated. or not.
But it's like Dcr. We increase Dcr by increasing Scr inn response to a later Ica.
VE is like that; it is the product of doing these other things. Targeting VE, IMO, is putting the cart before the horse.
Once you have a known VE, you can shuffle it back and forth or up and down, a bit, with other changes to target what you need, but it's a lotta work for very little gain.... IMO.
Getting 560cc of air into a 560cc hole is tough enough without it also having to be a streeter. Getting 560cc of air into a 750cc hole is a whole lot easier.