Yes, to error on the small side will have a higher velocity through the Venturi. This is good before boost kicks in. While under boost, the smaller carb can be power limiting.
Yes, striking the balance is about as easy as a NA engine.
Yes, the balance is where your comfortable at in having a machine drive, react while driving and it’s driving behavior at any rpm.
Details of the build would be super helpful as well as what the vehicle is intended for. How it is to be used.