Hughes stroker cam recommendation

Hughes reccomend these hydraulic roller cam for my future build. It wil be a 408. For my 67 dart. All steel, full street car. It will never see a track, just a fun street motor! Edelbrock heads.10.6-1 comp. Airgap intake. Car has a a518 with 3.91.
What is important is, does it work with aftermarket efi(holley sniper). The lsa 110 is maybe pushing it in combination with the duration?! 238 at 0.050.

Im also a little scared that while cruising the rpms are to low for the cam. Cruising 50 or 60 mph. I hope you guys get what i mean...