Apples to apples?..

I would say yes that you can compare apples to apples since nature itself doesn’t produce identical apples. So I believe that one can compare all engines of a specific displacement. The differences will be what is done with each of them during the build and the components used.
So when you say specific displacement should we just take this scenario for instance... Like a 383 bored out to a 408 and a small block 408 Stroker... Wouldn't a specific cam benefit one over the other? Wouldn't a specific carburetor benefit one over the other?.. and so on and so on?..