Hughes Whiplash Camshaft

Jim, I am almost 100% certain that intake has a common plenum. It will run on one carburetor. The fact that it's off center will have very little effect. Now if the plenums are isolated I could see it, but I don't think they are.
The plenums are isolated. One carb for 3 cylinders. Offy Offenhauser dual carb intake manifold for Slant 6 Mopar | eBay