Minimalist Slant Six draw-through build...

Here is something to ponder. There was no real drivability issues. Early Buicks and Pontiacs were draw through setups before EFI... I agree, stay away from the reed setup. Keep it simple and you'll have plenty of fun under 8 to 10 psi boost!
In the late 80's I built a six with forged TRW 8 to 1 pistons, ported head myself and installed 1.46" exhaust and 1.78 intake valves from Ford, .020 head gasket, ARP head and main studs, Crane "turbo" truck cam. I rebuilt a turbo used for an 81' Pontiac 301 draw through set up with a 600 Holley. Used a "J" pipe from the exhaust manifold up to the turbo. This very crude, low dollar, pile of parts withstood a high of 32 lbs of exhaust pressure to make 18 lbs of boost on 115 race gas. I added a fuel tank for the race gas and a three way ball valve to switch back to the stock fuel tank to drive to and from Maple Grove, Beaver Springs and Numidia Dragway. It usually ran low 13.0's at 104mph with 3.23 posi and sorely needed converter and trans brake but was too much money for the time. I had a lot of fun with my ugly green four door Valiant which as anyone can see was very inefficient by the exhaust pressure / boost ratio.