Head & cam selection...346 iron w/solid roller or Indy EZ w/XE285HL

Just askin here, as I don't have any experience doing that, but are there any premature wear problems when doing that?
I haven't found any yet Rob. We ran one in a 383, used it in a couple of demo derby cars and then installed the 383 into a '67 Coronet station wagon, drove it around for years, ran it on a chassis dyno at Mopars at the Strip where it made, gosh, seems like 300-330 RWHP. Has a little blowby now but next it is going into a 4x4 '68 Town and Country station wagon.