Best explanation I've seen so far for Hemi cam/lifter failures
It may not be a single item that causes failures. I tend to think it may be a combination of things.
Uncle Tony's theory may be a contributor for engines that see a lot of idling. When Chrysler asked Tom Hoover father of the Hemi) for design input he suggested raising the cam in the block. That's a design feature that will NEVER change.
MDS flaw thories are interesting. Larry Shepherd says in his Hemi book that there is no need to replace those lifters when disabling MDS, just run them as is. I do not have a high opinion of Shepherd after reading his stuff for a few decades.
FCA, or whatever the company is called these days, has never publicly admitted any fault. If they did, it would open up a huge monetary obligation. But, they have standardized on the heavy duty "Hellcat" replacement lifter across the board.
Whatever! I'm not deterred and going ahead with my 12,000 mile Eagle 5.7 swap. I have MDS plugs and 16 new factory Hellcat lifters to swap in. Good oil and filters and I'm hitting the road.
*****
EDIT: I wrote the above based on my 47 yrs of engineering, design and manufacturing experience. I just watched his video and the first half pretty much agrees with what i said. The G3 is not perfect but so what. Just fix it when it breaks.