Cylinder Head Porting and Power Production

I think it boils down to having a good match: expectation to engine choice; engine size to heads; heads to camshaft. The engines that excel with the magnum and vortec based ports show how good they are. the question is if you had say, that same engine as you started with, but with a large volume race ported head, and then stuck a set of EQs on it. Would it get better or worse? Why?