I used to use aleve and ibuprofen and the low dose aspirin... Since they caught a slight afib on a monitor they gave me Eliquis as 'an insurance policy' against stroke and said no more aspirin. And when they changed my BP meds said Tylenol is preferred to others. I'll do one 500 for a headache, up to a few time a day if I have something really hurting, but that does not happen often.