When to give up?

I can't provide much help, but to have you look at EVERY prescription you are on, especially any "psych meds". My wife battled suicidal tendencies for 27 years until she was taken OFF all psych meds. She has been battling GI problems for a year and a half. Both Pepcid and another acid reflux flux affected her mentally. Back when we were young the "pill" caused massive mood swings (the doc never did believe us).

No cliche is gonna help, but I'm sure you've heard 'em all...I know my wife did...