That is a very good point too. Mrs. Big John has a LCP that she doesn't like to shoot. Great carry gun, but not good for her to put boxes of ammo through at the range, so not a good gun for her to carry on a regular basis. On the other hand, I like my LCP and get a kick out of shooting it, so it's a good gun for me. I like my revolvers better, but that's another story.
I think it's been repeated here a few times.. You need to be comfortable with it in your hand. You also need to be comfortable at the range with it. I like to know that I've put at least a hundred rounds with no hiccups through any semi-auto before I would trust it to fire when my life depended on it. That's one factor. The other is that a gun that's I don't like to shoot won't get brought out when I'm at the range. You need to be comfortable shooting what you carry.
If I go plinking with the .22 revolver (lot's of fun), I at least run a couple loads of practice ammo through my carry gun.