I agree stock tune is like 5,200 Rev limiter so to wild of a cam won't see full potential. Then the fuel and timing curves. Fuel can somewhat be compensated for with injectors and fuel pressure. Timing crank sensor adjustment. But the actual curves are still the same.
I would do gears and a air intake first. Get a dakota or durango air hat and make your own air intake.
220 @050 is going to throw codes now I don't think that the transmission will go to limp mode though