Proform 850 dialing it in closer

The most logical approach might be to start at the top.
The top hole should just be at fuel level to start blowing some liquid up the well at beginning of pressure drop at the booster.
If the top hole is above fuel level, then plug it.

You know where the fuel level is from the sight plug or glass.
upload_2021-5-20_15-11-23-png.png

Comparing the e-hole positions with an older Holley block, it looks like the top hole and the 3rd hole down would be the ones to leave open.
upload_2021-8-27_8-31-32.png
I suppose if the fuel level is lower, then go for 2 & 4.
We're assume you only have the option of plugging and the factory has drilled the e-holes to something in the .026 to .028" range.