Not really. Torque is torque. Its real easy to detonate a turbo motor. Detonation is what kills blocks, well and brutal torque. The wives tales about what blocks break at are false. I made 800 on nitrous with a cast crank 360 and it lived for years that way.
My tune was really a mess for a long time. But the things I am super careful with are timing and fuel. Some people think I am too conservative but its what makes stuff live and I cant afford to throw money away because of impatience.