Thermoquad vs holley vs q-jets

Yes you redrill. The set screw just makes it tunable. If you go too big, just screw another blank in and start over. Sorry for the confusion, I think it but don’t type it.
I gotta add this, since we are here. In mild small blocks a lot of times you’ll notice that you idle mixture screws are 3 1/2 or more turns out. That is when I plug the idle bypass and do NOT redrill, or drastically reduce the size. This renders your idle mixture screws effective again.