We are putting a supersix intake on the slant in the grandsons duster and a 2245 holley carb. I

sure they do. A 2245 is the bigger 2 barrel made for a 360 or 400. Wont directly bolt to factory super 6 intake. They make adapters to go from the small 2 barrel pattern to the bigger 2 barrel intake pattern but then you might have hood clearance issues, and the linkage (especially kickdown) is gonna be a nightmare.