Mopar R3 Block

The 48 degree pushrod angle advantage should be quite evident especially since we are talking R3 blocks here and MOST don't use that block to build a 600 hp engine, also you stated stroke would be limited....which obviously to an extent but one of my engines is a 9.2" deck with a 4" stroke but is siamese bore and is it 4.165 and is roughly 434 cubic inches and makes excellent power so in my opinion a 9.2" deck is not a disadvantage in any way shape or form.
Yes, the 48° has a big advantage in a all out build, valve train stability especially, and the shorter deck combinations allow a lighter reciprocating weight, at the expense of long strokes. But the OP said he was interested in a big inch street build, with victor heads, and in THAT PARTICULAR case, the the 9.6 deck, 59° combo is going to be much simpler. And cheaper.