I avoid synthetic if possible. Maybe it's the old "synthetic causes oil leaks in older engine gaskets", or the fact that a friend who owned a rearend shop warranteed synthetic in rearends for six seconds or six inches, whichever came first.
Maybe it's the fact it's more expensive for no perceived benefit (to me).
I use it in the Camaro ss cause it's required. I have found no need for it elsewhere.