I wouldn't run iron heads unless there was a specific reason for it and if so they would be W2's and a ported set at that, if you have to keep a flat hood then maybe a ported Victor and or an Air Gap but if you will have some kind of scoop or clearance than a Super Victor.....again ported would be much better obviously, I run big carbs on everything I ever have owned but they all are some form of rowdy so as of yet no issues going that route and on my 415" street strip deal I ran a 970 Bigs prepped 4150 that worked quite good, the compression is low but maybe you said you did that because of the iron heads.......but again if you could run an aluminum head and with the right cam pick I think 11 maybe crowding 11.5-1 would be possible with a good tune on pump premium, then at minimum a set of step headers and depending how rowdy you got things maybe a set of 1 7/8's, also in my opinion a converter built off of a dyno sheet from a reputable company will net the biggest gain and or loss if not done correctly too in overall vehicle performance. That would be a start for me if I was doing a larger cubic inch stroker and it sounds like you want and or except some decent power from the package........525 hp should be ridiculously easy and 550-575 type range can be done with minimal effort all things considered.