Torque convertor and detonation

yes, but
I wouldn't be in big hurry to swap a known good-running carb for an unknown, onto an already detonation-prone engine with lo-stall TC, and 3.23s.
Your 500 is good to well over 5000rpm on your combo; how often will you go there?
Yes, I would set the T-slot and mixture screws AND float level, all the same