I've been daily driving my Duster for the past 6 years. Were there issues? Yes. But mostly easy to fix. I've driven long distances as well, did quite a few 500+ mile trips and did one 1200 mile trip in 2017. (planning another 1000+ mile trip in it soon)
Yes there were some squeaks but very mild as I've taken care of most of them. The wind noise is moderate but again I haven't replaced all the seals yet, and the interior is about 75% complete.
I currently have 3.21 rear gears. I can cruise comfortably at 71-72 mph. @ 3000 rpm, The exhaust drone is minimal (crossover pipes and straight-thru mufflers like Magnaflows are key).
Now keep in mind my suspension has been (and still is) slowly converted to aftermarket over the years. Now only the Lower Control Arms and rear suspension are OEM... For now.
I do plan on putting in an OD in mine soon, and change the rear end to 3.55 or 3.73.
Is she the most comfortable ride? Not quite, But it's loads better than before, but again I can likely improve her a little more... But man is it fun! She get's a lot of attention as well. (Both good and erm... bad).
Yes AC is a great thing as well. Luckily there are quite a few aftermarket options. As for seats I actually modified and mounted 1996 Mitsubishi Eclipse bucket seats into mine. Much better!
...