How to scuff up epoxy primer in order to spray the top coat?

Thanks for all the good information. Yes, barbee6043, it's the underside of the car and I'm going to top coat it with some PCC industrial semi-gloss black catalyzed urethane (single stage), so I'm not all that concerned about how it looks, so I think I'll just use the red Scotchbrite pads, call the scuffing good and then spray the urethane.
OK. Since you appear to be going for a nice semi-gloss black underside, the scuffing will work fine. That isn't how I do it, but I am old and set it my ways. Just be careful about one thing! You need to THOROUGHLY scuff it. If you leave any shiny spots, those spots will NOT have 'tooth' or mechanical adhesion for the paint to stick to, and you will have problems down the road. Also, please note that like sandpaper, a piece of scuffing pad does not last forever. when it stops scuffing/cutting, switch to a new piece. and make sure you wipe/clean the scuffed surface down with a pre-paint cleaner and hit the surface with a tack cloth. Good luck, and POST PICTURES OF YOUR RESULTS.