I'll disagree somewhat (but spare the red X BS. LOL )
Yup. That's why its worth running the numbers through pipemax and following Larry's guidance when running a full exhaust. It's certainly possible to stuff up a system even with (especially with?) larger pipes. I've done it. Every disruption in flow can be controlled so a full exhaust doesn't have to ruin a header's potential. It's why the H pipe, X pipe arguement is pointless. When either is used, whether they are effective or detrimental is about sizing and placement and the rest of the system.