I wouldn't worry at all at 10.5:1 compression on 91 octane, especially with aluminum heads. As earlier stated, I run 10.12:1 with iron heads on 91 octane, and a cam with 106 degree lobe seperation angle. Tight closed chambers, quench, and dished pistons, combined with proper timing, and tuning and you will be fine. Unless you zero deck the block, I suspect your compression in reality, will come out lower than the math on the parts says it will be.
@autoxcuda my post is in no way meant to say you are incorrect, as I realized after typing, it may sound. I am mearly relating my experiences with 91 octane. My friend Murray, has a 410 stroker, with Eddy heads, and 10.5:1 compression, and a solid lifter flat tappet cam with 244 degrees duration at .050. Neither he, or I are experiencing any detonation on 91 octane, at around 3000ft.