Yes. When the carbs are in-line and you are using center hung float bowls the fuel slosh will shut the needle and seats off.
If you mount them in-line and use those shitty small bowls like the 4224 (660 center squirter) or the 1850 (universal fit 600 vacuum secondary carb that universally fit nothing) you give up too much fuel volume.
Plus the fuel moves around enough in the small bowls to shut off the needle and seats.
The only issue with sideways carbs is the linkage and it’s really very simple.