When I look at most builds making similar power, I find the parts are similar across cid and brands and when you factor in the stall and gearing most the differences disappear.
Not saying that, I would think it's combo dependent, obviously generic top parts may favor different bottom ends is it always 100% the larger one? I don't see a 400 need 50-60 more degrees of cam and 50-100 cfm head flow etc.. to make 600 hp compared to a 500.