To Turbo or Supercharge

TT5.9mag said
E85 is a great fuel choice. I’m curious why you say,
“.particularly for the turbo keeping charge temps in check.”
Turbos do not beat the air and heat it up any more than a centrifugal or (worse) a roots supercharger does. E85 will help the charge air temps regardless of the type of supercharging. Certainly not enough to consider not using an intercooler on the level of boost being discussed here.

Draw-thru carb vs mpfi, the turbo body heats the inlet air even w/o boosting, draw-thru w/alky will help cool it. I have no idea what the OP is envisioning here, so just bringing some info to light. 400 hp isn't that lofty an output achievement, but durability as You say, is going to require a lot of attn.