Single or Twin turbo setup for 360?

I would probably choose a single unit over a twin setup myself for simplicity’s sake and cost. @TT5.9mag would probably have some good input here. With towing and boost, you’re looking at extended periods of high load usage and heat build up, so the tune becomes much more critical. I’ve known of Chrysler big block motorhomes that were outfitted with turbos, so it is possible.