When I was spec'ing out my 408" Procharger build I got guidance from some old schoolers. Wide LSA (114), 8.5 compression, ..... It ran beautifully but was pretty tame "feeling" for making 650 hp and 600 ftlb.
In the next 6 months I plan on pulling it from the 'cuda and going through it (sitting for years). It is a hydraulic roller LA engine with bushed lifter bores. I am going to look into a little more duration (230 @.050"?) and around 110 LSA. Maybe even mill the heads for a little more compression.
I have a new Snow water/meth injection system to put on this time too. Intercooler would be the preferred cooling but package constraints force the decision. I was thinking about putting that engine in my 76 D100 and couldn't find an overly roomy area , even on the truck, for an intercooler big enough. You can always do surgery on the trucks radiator core support and possibly space your whole radiator back about 1/2" (run electric fans?).
On my 76 there is a brace that connects the top and bottom of the core support right in the middle. Move that and space the radiator back and it would be enough room for the IC. I am unfamiliar with what the next generation's core and grille area look like.