Port-o-sonic or Holley Street Dominator?

You'll be close to that by the time you get bungs machined and welded into an existing manifold and have to get custom fuel rails made up- and still be saddled with a "compromise" manifold. Then there's the throttle body adapter and other miscellaneous hardware that's included in the Hughes kit (which also accepts stock fuel rails). Not to mention that the LA manifolds that you mention won't work with the Magnum serpentine drive, requiring you to swap to the LA TC cover, water pump and v-belt drive. It adds up fast.
Do the Speedmaster heads you're looking at take LA or Magnum intakes?
You do make good points there, I’ll definitely do some number crunching before it all happens. That said, call me weird, but one draw to using a different intake over the Hughes one is the challenge of figuring everything out to make it work. I do plan to use the factory magnum rails, regardless what manifold I use, and probably use a 4 barrel throttle body if I use a modified intake.
Also, if the Hughes intake, adapter and tb are even a 1/4” higher than my current China-gap and edelbrock carb are, I won’t be able to run it. My engine is raised 3/4-1” and even with a 2” drop base my air cleaner lid JUST touches the underside of my hood.
Oh, I completely forgot, my speedmaster heads are la intake pattern.