Rear End Question

I have four pairs of centerlines with rim screws, and I didn't do any of them, lol. It seems like the bigger the rim, the more power, the more the likelihood of rim screws and the larger the quantity.
I don't understand why on one wheel only. If it needed them on one wheel, it probably needed them on both.
I'm curious, on the inside of the wheel too, or just on the outside?