340 stroker 422

At 108 your overlap triangle is centered (where it should be) and you are closing the intake valve 4 degrees later (@ .050) and that’s two big things.

I also question your gear selection. Unless you have a very short tire you will constantly be lugging the engine, or at least be far enough below peak torque that you are on the edge of detonation.
Tire will be 27 or 28” tall, copper cobra 275 or 295.
I was planning to use mild timing curve in msd distributor, also limit max timing and use cold plugs.