318 MAX fuel economy builds?

So my current question is... when in terms of achieving maximum fuel economy should I raise the compression ratio up to the brink of detonation? Assuming I go the route of, let's say, an RV cam, should I push it to 10:1 or so or should I drop the the compression ratio into the 8:1 or so range? I understand compression ratio when it comes to maximizing performance but I have never in my time yet made an engine for best mpg so this is exploring the land of the unknown for me. I think if I can find one I would attempt to use the Holley Economaster carb but if not I will use a TQ with the secondaries unhooked and possibly an OD trans with roughly 3.55 gears out back. Thoughts? Input?