318 MAX fuel economy builds?

So I'm looking into buying a long-distance capable daily driver. I have my eyes on a Dodge Diplomat and Chrysler 5th Avenue. Both have 318s and I thought it may be of my own interest to buy one as a daily as they are things I can work on instead of things I would need to take to a shop. In the case that I buy one or the other I would like to build the 318 for high fuel economy, I'm talking like 20+ mpg if possible. Anyone done this? Any input? Etc. Let's coffee-table talk daily stuff instead of high horsepower for once.
I have some pieces to do an economy mileage build, a 69 318 block,

an Edelbrock 318 Streemaster, designed for mileage and tork, (idle to all done at 4500) on a stock 318, will be interesting to to see what happens with a custom cam.

A 400 cfm Old style AFB or tweaked Thermoquad

273 closed chamber heads, haven't calculated the compression increase yet,

Thinking of Howard's Cams for a custom grind.

76 A833 aluminum overdrive transmission 4 speed with .79 final ratio

2.76 gears 27 tires

1 5/8 Doug's 453 headers


I don't see any reason that I can't get 25 mpg